The five-time European Tour winner broke through to win his first major championship in July 2019 at The Open Championship at Royal Portrush in Northern Ireland, besting Tommy Fleetwood, of England, by six strokes. Previously, the Irishman was in contention to win the 2016 U.S. Open at Oakmont until three consecutive bogeys from No. 14 pushed him to a share of second place, three strokes behind winner Dustin Johnson. He also tied for ninth at Chambers Bay a year earlier. Lowry broke through for his first victory on U.S. soil by two strokes over Bubba Watson in the 2015 WGC-Bridgestone Invitational at Firestone Country Club. As an amateur, Lowry won the 2009 Irish Open. He also represented Ireland in the 2008 World Amateur Team Championship.
| Year | Site | Scores | To Par | Finish |
| 2020 | Winged Foot Golf Club (West Course) | 76-70-77-72--295 | +15 | T-43 |
| 2019 | Pebble Beach Golf Links | 75-69-70-69--283 | -1 | T-28 |
| 2018 | Shinnecock Hills Golf Clulb | 75-79 | +14 | MC |
| 2017 | Erin Hills | 71-74-73-73--291 | +3 | T-46 |
| 2016 | Oakmont Country Club | 68-70-65-76--279 | -1 | T-2 |
| 2015 | Chambers Bay | 69-70-70-71--280 | E | T-9 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 73-73 | +6 | MC |
| 2011 | Congressional Country Club | 72-76 | +6 | MC |