Kisner registered his third PGA Tour victory in March, defeating Matt Kuchar, 3 and 2, in the championship match of the WGC-Dell Technologies Match Play at Austin (Texas) Country Club. It came a year after he lost in the championship match to Bubba Watson. His previous victory had come in the 2017 Dean & Deluca Invitational at Colonial Country Club. He was in a playoff at the 2015 Players Championship with Sergio Garcia and eventual winner Rickie Fowler. Kisner was a member of the 2005 NCAA championship team at the University of Georgia with fellow PGA Tour players Brendon Todd and Chris Kirk, along with 2001 U.S. Junior Amateur runner-up Richard Scott. He also has won twice on Web.com Tour. He represented the USA on the victorious 2017 Presidents Cup Team.
| Year | Site | Scores | To Par | Finish |
| 2019 | Pebble Beach Golf Links | 73-70-75-69--287 | +3 | T-49 |
| 2018 | Shinnecock Hills Golf Club | 77-75 | +12 | MC |
| 2017 | Erin Hills | 74-70-76-76--296 | +8 | T-58 |
| 2016 | Oakmont Country Club | 73-71-71-76--291 | +11 | T-49 |
| 2015 | Chambers Bay | 71-68-73-69--281 | +1 | T-12 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 75-77 | +12 | MC |