Kisner broke through for his first PGA Tour victory in November 2015, shooting weekend rounds of 64-64 to win the RSM Classic at Sea Island Golf Club in Georgia. He earned his second PGA Tour win last May at the Dean & Deluca Invitational at Colonial Country Club. He was in a playoff at the 2015 Players Championship with Sergio Garcia and eventual winner Rickie Fowler, and advanced to the championship match of the 2018 WGC-Dell Technologies Match Play Championship at Austin (Texas) Country Club before falling to Bubba Watson, 7 and 6. Kisner was a member of the 2005 NCAA championship team at the University of Georgia with fellow PGA Tour players Brendon Todd and Chris Kirk, along with 2001 U.S. Junior Amateur runner-up Richard Scott. He also has won twice on Web.com Tour. Last fall, he represented the USA on the victorious Presidents Cup Team.