Mickelson has a record six runner-up finishes in the U.S. Open, and needs a U.S. Open title to complete the career Grand Slam. His last major championship victory came in 2013 when he shot a final-round 66 to win the 2013 Open Championship conducted by The R&A at Muirfield. He also owns three Masters victories, in 2004, 2006 and 2010, and he won the PGA Championship in 2005 at Baltusrol Golf Club in Springfield, N.J. A 2012 World Golf Hall of Fame inductee, Mickelson has 52 worldwide wins, including 43 on the PGA Tour. Ended a five-year victory drought earlier this year in a one-hole playoff with Justin Thomas at the WGC-Mexico Championship. His only USGA title came in the 1990 U.S. Amateur at Cherry Hills Country Club over fellow San Diegan Manny Zerman. He represented the USA in the 1989 and 1991 Walker Cup Match and is a three-time NCAA individual champion. As a professional, he has competed on 11 USA Ryder Cup and 12 Presidents Cup teams.
| Year | Site | Scores | To Par | Finish |
| 2018 | Shinnecock Hills Golf Club | 77-69-81-69--296 | +16 | T-48 |
| 2016 | Oakmont Country Club | 74-73 | +7 | MC |
| 2015 | Chambers Bay | 69-74-77-73--293 | +13 | T-64 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 70-73-72-72--287 | +7 | T-28 |
| 2013 | Merion Golf Club | 67-70-72-74--283 | +3 | T-2 |
| 2012 | The Olympic Club | 76-71-71-78--296 | +16 | T-65 |
| 2011 | Congressional Country Club | 74-69-77-71--291 | +7 | T-54 |
| 2010 | Pebble Beach Golf Links | 75-66-73-73--287 | +3 | T-4 |
| 2009 | Bethpage State Park (Black Course) | 69-70-69-70--278 | -2 | T-2 |
| 2008 | Torrey Pines (South Course) | 71-75-76-68--290 | +6 | T-18 |
| 2007 | Oakmont Country Club | 74-77 | +11 | MC |
| 2006 | Winged Foot Golf Club (West Course) | 70-73-69-74--286 | +6 | T-2 |
| 2005 | Pinehurst Resort & C.C. (Course No. 2) | 69-77-72-74--292 | +12 | T-33 |
| 2004 | Shinnecock Hills Golf Club | 68-66-73-71--278 | -2 | 2 |
| 2003 | Olympia Fields Country Club | 70-70-75-74--289 | +9 | T-55 |
| 2002 | Bethpage State Park (Black Course) | 70-73-67-70--280 | E | 2 |
| 2001 | Southern Hills Country Club | 70-69-68-75--282 | +2 | T-7 |
| 2000 | Pebble Beach Golf Links | 71-73-73-76--293 | +9 | T-16 |
| 1999 | Pinehurst Resort & C.C. (Course No. 2) | 67-70-73-70--280 | E | 2 |
| 1998 | The Olympic Club | 71-73-74-70--288 | +8 | T-10 |
| 1997 | Congressional Country Club | 75-68-73-74--290 | +10 | T-43 |
| 1996 | Oakland Hills C.C. (South Course) | 76-71-73-76--296 | +16 | T-94 |
| 1995 | Shinnecock Hills Golf Club | 68-72-70-74--284 | +4 | T-4 |
| 1994 | Oakmont Country Club | 75-70-73-79--297 | +13 | T-47 |
| 1992 | Pebble Beach Golf Links | 68-81 | +5 | MC |
| 1991 | Hazeltine National Golf Club | 73-72-80-75--300 | +12 | T-55 |
| 1990 | Medinah Country Club (No. 3) | 74-71-71-72--288 | E | T-29 |