The owner of 11 worldwide victories will make his sixth U.S. Open start after getting into the field by being among the top 70 points leaders in the Official World Golf Ranking as of March 15. Wiesberger owns seven European Tour victories, the last of which came in the 2019 Italian Open. It was one of three wins in 2019 for the Austrian. Wiesberger also represented his country in the World Amateur Team Championship in 2004 and 2006.
U.S. Open Record
| Year | Site | Scores | To Par | Finish |
| 2020 | Winged Foot Golf Club (West Course) | 73-72-76-74--295 | +15 | T-43 |
| 2019 | Pebble Beach Golf Links | 71-73-78-72--294 | +10 | 76 |
| 2017 | Erin Hills | 69-72-69-73--283 | -5 | T-16 |
| 2016 | Oakmont Country Club | 76-72 | +8 | MC |
| 2015 | Chambers Bay | 72-75 | +7 | MC |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 72-78 | +10 | MC |