The owner of 12 worldwide victories will make his seventh U.S. Open start after getting into the field via the Top 60 in the Official World Golf Ranking as of June 7. Wiesberger owns eighth European Tour victories, the last of which came on May 30 at the Made in Himmerland in Denmark. The Austrian also produced three victories in 2019. Wiesberger represented his country in the World Amateur Team Championship in 2004 and 2006.
U.S. Open Record
| Year | Site | Scores | To Par | Finish |
| 2021 | Torrey Pines Golf Course (South Course) | 75-72 | +5 | MC |
| 2020 | Winged Foot Golf Club (West Course) | 73-72-76-74--295 | +15 | T-43 |
| 2019 | Pebble Beach Golf Links | 71-73-78-72--294 | +10 | 76 |
| 2017 | Erin Hills | 69-72-69-73--283 | -5 | T-16 |
| 2016 | Oakmont Country Club | 76-72 | +8 | MC |
| 2015 | Chambers Bay | 72-75 | +7 | MC |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 72-78 | +10 | MC |