Grace rose on the U.S. Open scene in 2015 at Chambers Bay (T-4) and continued his fine play at Oakmont (T-5) in 2016. He also finished third in the 2015 PGA Championship at Whistling Straits (he tied for fourth in 2016 at Baltusrol Golf Club) and then won for the first time on U.S. soil in April 2016 at the RBC Heritage. Eight of his 12 professional victories have come on the European Tour; his last coming at the 2017 Nedbank Golf Challenge. Grace represented the International Team in the 2013 and 2015 Presidents Cups. During the third round of The Open Championship in 2017 at Royal Birkdale, he became the first player to ever shoot a 62 in a major championship.
U.S. Open Record
| Year | Site | Scores | To Par | Finish |
| 2019 | Pebble Beach Golf Links | 75-71 | +4 | MC |
| 2018 | Shinnecock Hills Golf Club | 76-69-72-75--292 | +12 | T-25 |
| 2017 | Erin Hills | 72-72-71-77--292 | +4 | T-50 |
| 2016 | Oakmont Country Club | 73-70-66-71--280 | E | T-5 |
| 2015 | Chambers Bay | 69-67-70-71--277 | -3 | T-4 |
| 2013 | Merion Golf Club | 70-83 | +13 | MC |
| 2012 | The Olympic Club | 71-74-73-75--293 | +13 | T-51 |