The 122nd U.S. Open will be Scott's 84th consecutive start in a major, but that streak was in jeopardy in June 2018 when the affable Australian needed to survive final qualifying in Columbus, Ohio, to earn his place in the field at Shinnecock Hills. In 2013, he became the first Australian to win the Masters after defeating 2007 U.S. Open champion Angel Cabrera in a playoff. Scott, who briefly attended the University of Nevada-Las Vegas, has been a global traveler since turning pro in 2000, with 31 worldwide wins, including 14 on the PGA Tour. His last win on that circuit was the 2020 Genesis Invitational at The Riviera Country Club. He also won the PGA Tour's Honda Classic and World Golf Championships-Cadillac Championship in consecutive weeks in March 2016. Scott shot a final-round 64 in the 2015 U.S. Open at Chambers Bay to post his best career finish in the championship (T-4). Has been a member of nine International Presidents Cup teams.
U.S. Open Record
| Year | Site | Scores | To Par | Finish |
| 2022 | The Country Club | 69-73-72-68--282 | +2 | T-14 |
| 2021 | Torrey Pines Golf Course (South Course) | 70-75-71-73--289 | +5 | T-35 |
| 2020 | Winged Foot Golf Club (West Course) | 71-74-74-75--294 | +13 | T-38 |
| 2019 | Pebble Beach Golf Links | 70-69-71-68--278 | -6 | T-7 |
| 2018 | Shinnecock Hills Golf Club | 78-75 | +13 | MC |
| 2017 | Erin Hills | 72-75 | +3 | MC |
| 2016 | Oakmont Country Club | 71-69-72-74--286 | +6 | T-18 |
| 2015 | Chambers Bay | 70-71-72-64--277 | -3 | T-4 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 73-67-73-69--282 | +2 | T-9 |
| 2013 | Merion Golf Club (East Course) | 72-75-73-75--295 | +15 | T-45 |
| 2012 | The Olympic Club (Lake Course) | 76-70-70-70--286 | +6 | T-15 |
| 2011 | Congressional Country Club (Blue Course) | 74-73 | +5 | MC |
| 2010 | Pebble Beach Golf Links | 77-73 | +8 | MC |
| 2009 | Bethpage State Park (Black Course) | 69-71-73-75--288 | +8 | T-36 |
| 2008 | Torrey Pines Golf Course (South Course) | 73-73-75-70--291 | +7 | T-26 |
| 2007 | Oakmont Country Club | 76-82 | +16 | MC |
| 2006 | Winged Foot Golf Club (West Course) | 72-76-70-74--292 | +12 | T-21 |
| 2005 | Pinehurst Resort & C.C. (Course No. 2) | 70-71-74-76--291 | +11 | T-28 |
| 2004 | Shinnecock Hills Golf Club | 75-75 | +10 | MC |
| 2003 | Olympia Fields Country Club (North Course) | 72-72 | +4 | MC |
| 2002 | Bethpage State Park (Black Course) | 77-80 | +17 | MC |