Horschel will make his 10th U.S. Open start thanks to his victory in the 2021 BMW PGA Championship at Wentworth, the flagship event on the DP World Tour (formerly European Tour). The former University of Florida star owns six PGA Tour victories, the latest coming in the WGC-Dell Technologies Match Play where he defeated 2013 U.S. Junior Amateur champion and future Masters champion Scottie Scheffler, 2 and 1, in the 18-hole final. Horschel closed out the 2014 season by winning the BMW Championship and Tour Championship to claim the FedExCup title. Horschel shared the 36-hole lead with Phil Mickelson in the 2013 U.S. Open at Merion, where he tied for fourth. He was a member of the victorious 2007 USA Walker Cup Team. He also holds the USGA 18-hole scoring record, shooting a 60 at the Chaska (Minn.) Town Course in the first round of the 2006 U.S. Amateur. Horschel also represented the USA in the 2007 and 2008 Palmer Cups.
U.S. Open Record
| YEAR | SITE | SCORES | TO PAR | FINISH |
| 2021 | Torrey Pines Golf Course (South Course) | 74-75 | +7 | MC |
| 2020 | Winged Foot Golf Club (West Course) | 72-70-72-80--294 | +14 | T-38 |
| 2019 | Pebble Beach Golf Links | 73-70-71-70--284 | E | T-32 |
| 2017 | Erin Hills | 79-78 | +13 | MC |
| 2016 | Oakmont Country Club | 72-74-66-76--288 | +8 | T-32 |
| 2015 | Chambers Bay | 72-72-73-67--284 | +4 | T-25 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 75-68-73-70-286 | +6 | T-23 |
| 2013 | Merion Golf Club (East Course) | 72-67-72-74--285 | +5 | T-4 |
| 2006 | Winged Foot Golf Club (West Course) | 75-77 | +12 | MC |