The former Oklahoma State All-American outlasted Sergio Garcia and Kevin Kisner in a playoff to win the 2015 Players Championship for his biggest PGA Tour victory to date. Although Fowler has yet to register a major-championship victory, he came very close in April, falling one stroke short of champion Patrick Reed. Fowler owns four PGA Tour victories, his last coming at the 2017 Honda Classic. Fowler's best U.S. Open finish came in 2014 at Pinehurst when he shared second place with Erik Compton; he tied for 10th in the 2013 U.S. Open at Merion Golf Club, a venue where he helped the USA Walker Cup Team defeat GB&I in 2009. Fowler also played on the victorious 2007 USA Walker Cup Team. He's been a member of the 2010, 2014 and 2016 U.S. Ryder Cup Teams and the 2015 and 2017 U.S. Presidents Cup Teams. In 2014, he finished in the top five of all four majors, one of four players (Jack Nicklaus, Tiger Woods and Jordan Spieth) to achieve the feat, but the only one to not register a victory.
| Year | Site | Scores | To Par | Finish |
| 2018 | Shinnecock Hills Golf Club | 73-69-84-65--291 | +11 | T-20 |
| 2017 | Erin Hills | 65-73-68-72--278 | -10 | T-5 |
| 2016 | Oakmont Country Club | 76-75 | +11 | MC |
| 2015 | Chambers Bay | 81-73 | +14 | MC |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 70-70-67-72 | -1 | T-2 |
| 2013 | Merion Golf Club | 70-76-67-74--287 | +7 | T-10 |
| 2012 | The Olympic Club | 72-76-71-72--291 | +11 | T-41 |
| 2011 | Congressional Country Club | 74-73 | +5 | MC |
| 2009 | Bethpage State Park (Black Course) | 78-68 | +6 | MC |
| 2008 | Torrey Pines (South Course) | 70-79-76-72--297 | +13 | T-60 |