The former Oklahoma State All-American ended a two-year victory drought with his two-stroke win in the 2019 Waste Management Phoenix Open. His biggest victory to date came in the 2015 Players Championship when he outlasted Sergio Garcia and Kevin Kisner in a playoff. Although the five-time PGA Tour winner has yet to register a major-championship victory, he came very close in the 2017 Masters, falling one stroke short of champion Patrick Reed. Fowler's best U.S. Open finish came in 2014 at Pinehurst when he shared second place with Erik Compton; he tied for 10th in the 2013 U.S. Open at Merion Golf Club, a venue where he helped the USA Walker Cup Team defeat GB&I in 2009. Fowler also played on the victorious 2007 USA Walker Cup Team. He's been a member of the 2010, 2014, 2016 and 2018 U.S. Ryder Cup Teams and the 2015, 2017 and 2019 U.S. Presidents Cup Teams. In 2014, he finished in the top five of all four majors, one of four players (Jack Nicklaus, Tiger Woods and Jordan Spieth) to achieve the feat, but the only one to not register a victory.
| Year | Site | Scores | To Par | Finish |
| 2020 | Winged Foot Golf Club (West Course) | 69-77-72-79--297 | +17 | T-49 |
| 2019 | Pebble Beach Golf Links | 66-77-71-72--286 | +2 | T-43 |
| 2018 | Shinnecock Hills Golf Club | 73-69-84-65--291 | +11 | T-20 |
| 2017 | Erin Hills | 65-73-68-72--278 | -10 | T-5 |
| 2016 | Oakmont Country Club | 76-75 | +11 | MC |
| 2015 | Chambers Bay | 81-73 | +14 | MC |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 70-70-67-72 | -1 | T-2 |
| 2013 | Merion Golf Club | 70-76-67-74--287 | +7 | T-10 |
| 2012 | The Olympic Club | 72-76-71-72--291 | +11 | T-41 |
| 2011 | Congressional Country Club | 74-73 | +5 | MC |
| 2009 | Bethpage State Park (Black Course) | 78-68 | +6 | MC |
| 2008 | Torrey Pines (South Course) | 70-79-76-72--297 | +13 | T-60 |