The Floridian will make his seventh U.S. Open start after earning his place in the field by qualifying for the season-ending Tour Championship last year. Berger recorded his fourth PGA Tour victory in February at the AT&T National Pro-Am at Pebble Beach (Calif.) Golf Links by three strokes over Brooks Koepka, Phil Mickelson and Steve Stricker. His previous win came in the 2020 Charles Schwab Challenge at Colonial Country Club in Fort Worth, Texas, in a playoff over Collin Morikawa when the PGA Tour restarted following a 3-month hiatus due to the COVUD-19 pandemic. The former Florida State All-American was named the PGA Tour's Rookie of the Year for the 2014-15 season. He tied for second in the 2013 NCAA Division I Championship and was a member of the victorious USA Palmer Cup Team. In 2017, he played on the victorious USA Presidents Cup Team. His father, Jay, is a former professional tennis player who has coached at the University of Miami (Fla.) and Florida International as well as with the U.S. National Team.
| Year | Site | Scores | To Par | Finish |
| 2021 | Torrey Pines Golf Course (South Course) | 71-72-72-68--283 | -1 | T-7 |
| 2020 | Winged Foot Golf Club (West Course) | 73-70-74-76--293 | +13 | T-34 |
| 2019 | Pebble Beach Golf Links | 73-70-74-70--287 | +3 | T-49 |
| 2018 | Shinnecock Hills Golf Club | 76-71-66-73--286 | +6 | T-6 |
| 2017 | Erin Hills | 78-75 | +9 | MC |
| 2016 | Oakmont Country Club | 70-72-70-77--289 | +9 | T-37 |
| 2014 | Pinehurst Resort & C.C. (Course No. 2) | 72-71-78-66--287 | +7 | T-28 |